Week 9 was the week the favorites finally broke through. Jacksonville, Cincinnati, Kansas City, Houston, San Francisco, and Buffalo all won by at least 17 points, while Green Bay upset New England 45-27. Faves finished 11-3-1 against the spread (ATS), while totals remained a coin flip, going 7-8 overall.
Week 10 brings seven divisional games, a Sunday morning matchup in Munich and a Monday night meeting between two teams desperate to reverse their seasons. Four teams are on bye, but with division battles and Jacksonville making a ton of deadline trades, there’s plenty to consider for NFL Week 10 odds. Here’s a preview of the biggest matchups, players to watch, and NFL Week 10 betting trends.
*All spreads, moneylines, and totals are subject to change.
NFL Week 10 Games to Watch
Thursday, Nov. 12: Washington Commanders at New York Giants – 8:15 p.m. ET, Prime Video
- Spread: Giants -2
- Moneyline: Commanders +105; Giants -125
- Total: 42
New York is 5-2-1 after holding Philadelphia to 11 points, while Washington slipped to 2-5-1. Their first meeting ended 27-27 with the Giants listed at +3.5. The Commanders have had a disappointing first half, covering in only two games and averaging a -3.8 margin of victory. On the injury report, J.J. McCarthy and Cam Skattebo were limited in practice, while Jayden Daniels practiced fully.
Check the latest Commanders vs. Giants odds and picks before kickoff.
Sunday, Nov. 15: New England Patriots at Detroit Lions – 9:30 a.m. ET, FOX
- Spread: Lions -3
- Moneyline: Patriots +135; Lions -160
- Total: 51.5
On paper, Detroit’s defense rebounded by limiting Miami to nine points, but was it their defense or Miami’s inept offense? They get a real test against New England, which has offensive firepower behind it but is prone to exploitable mistakes. The neutral-site game in Munich carries a 51.5 total, showing that oddsmakers expect Jared Goff and Drake Maye to attack two secondaries that have allowed explosive plays.
Check the latest Patriots vs. Lions odds and picks before kickoff.
Sunday, Nov. 15: Jacksonville Jaguars at Tennessee Titans – 1 p.m. ET, FOX
- Spread: Titans +10.5
- Moneyline: Jaguars -540; Titans +400
- Total: 46
Jacksonville followed a 42-point performance against Indianapolis with a 33-10 win at Baltimore. Tennessee comes out of its bye at 1-7 and is the only Week 10 home team opening as double-digit homedogs. An efficient Trevor Lawrence should lead to a Jags win; the question remains whether they can cover a big spread on the road.
Check the latest Jaguars vs. Titans odds and picks before kickoff.
Sunday, Nov. 15: Kansas City Chiefs at Atlanta Falcons – 1 p.m. ET, CBS
- Spread: Falcons +3
- Moneyline: Chiefs -185; Falcons +160
- Total: 45.5
Kansas City moved to 6-2 by dismantling the Jets 35-12, while Atlanta returns from Madrid after a 34-17 loss. The three-point spread shows the market still respects the Falcons at home. Bijan Robinson must help Atlanta keep Patrick Mahomes on the sideline.
Check the latest Chiefs vs. Falcons odds and picks before kickoff.
Sunday, Nov. 15: San Francisco 49ers at Dallas Cowboys – 4:25 p.m. ET, FOX
- Spread: Cowboys +4
- Moneyline: 49ers -215; Cowboys +176
- Total: 55.5
The week’s highest total pairs 7-1 San Francisco with a Dallas team that just survived lowly Indianapolis. CeeDee Lamb produced 180 receiving yards on downfield targets last week, giving the Cowboys a route to matching the 49ers – provided Dallas keeps Dak Prescott clean.
Check the latest 49ers vs. Cowboys odds and picks before kickoff.
Sunday, Nov. 15: Pittsburgh Steelers at Cincinnati Bengals – 8:20 p.m. ET, NBC
- Spread: Bengals -3.5
- Moneyline: Steelers +167; Bengals -195
- Total: 48.5
Cincinnati has won four straight, but Pittsburgh is also 6-2 and returns from its bye. The Steelers won the first meeting 30-27, making the hook beyond a field goal important. Pittsburgh’s best route to another upset is shortening the game.
Check the latest Steelers vs. Bengals odds and picks before kickoff.
Monday, Nov. 16: Los Angeles Chargers at Baltimore Ravens – 8:15 p.m. ET, ESPN
- Spread: Ravens -5
- Moneyline: Chargers +195; Ravens -235
- Total: 38.5
Los Angeles remains winless after surrendering 44 points to Houston, while Baltimore fell below .500 after a 33-10 loss. The Ravens are five-point favorites, but the super-low 38.5 total reflects two troubled offenses. Field position and red-zone execution may decide it.
Check the latest Chargers vs. Ravens odds and picks before kickoff.
Key Players to Watch in NFL Week 10
Here are three starters that could exceed or fall below player prop expectations.
- Jared Goff, QB, Detroit Lions – Better Than Expected: New England just allowed 45 points, and a 51.5 total gives Goff multiple-touchdown potential.
- CeeDee Lamb, WR, Dallas Cowboys – Better Than Expected: A likely pass-heavy script and 55.5 total create room for another ceiling performance.
- Joe Burrow, QB, Cincinnati Bengals – Lower Than Expected: Pittsburgh is rested, already beat Cincinnati once, and is 6-2 ATS.
NFL Week 10 Betting Trends
- Week 9 favorites: Favorites went 11-3-1 ATS last week. This was the best performance by favorites this year.
- Last year’s Week 10: Five underdogs won outright, while overs and unders split 7-7.
- Road-team value: Road teams are 73-55-8 ATS through nine weeks of 2026.
- ATS extremes: The Giants and Steelers are 6-2 ATS; the Chargers are 0-7-1.
- The biggest spread: Jacksonville is the only double-digit favorite, laying 10.5 at Tennessee.
- The totals range: 49ers-Cowboys is highest at 55.5; Chargers-Ravens is lowest at 38.5.
NFL Week 10 FAQs
When does NFL Week 10 begin?
Week 10 begins Thursday, Nov. 12, when the Washington Commanders visit the New York Giants at 8:15 p.m. ET on Prime Video.
Where can I find NFL Week 10 odds?
Bovada offers NFL Week 10 odds including spreads, moneylines, totals, player props, and promotions for same-game parlays.
Which teams have a bye in NFL Week 10?
The Chicago Bears, Denver Broncos, Philadelphia Eagles, and Tampa Bay Buccaneers are on bye.